Treatment of chronic endometritis in dogs. Diagnosis and treatment of endometritis in dogs

Inflammation of the uterine mucosa occurs primarily as a postpartum complication. However, one should remember about the provoking influence of pathological pregnancy, imaginary pregnancy, as well as estrus disruptions with synthetic hormonal agents. You need to be wary of the occurrence of endometritis in following situations:

1. Large fruit. Puppies injure the mucous membrane, opening access to conditionally pathogenic microflora.
2. Retention of placenta. It occurs due to an unbalanced diet and lack of walking.
3. Decomposition of dead fetuses during pathological pregnancy.
4. Infection during obstetrics.

Consequences

Complications of endometritis lead to the following diseases and pathological conditions:

1. Pyometra. Purulent inflammation of the uterus ends with its extirpation or death of the animal.
2. Infection in the kidneys. Development of pyelonephritis or chronic renal failure.
3. Uterine rupture, peritonitis.

Symptoms

Endometritis occurs acutely and chronically. The manifest course is characteristic of postpartum period. After 3–7 days, the whelping bitch will develop the following symptoms: clinical symptoms:

• loss of appetite followed by complete starvation;
• thirst;
• vomit;
• hyperthermia;
• frequent urge to urination, mostly false;
• the stomach swells and sags;
• milk disappears;
• cloudy, colored, foul-smelling vaginal excreta appears.

The chronic course appears 6–8 weeks after whelping. Permanent endometritis is detected during estrus, it passes sluggishly, the bitch drives away males. If mating occurs, the puppies are born dead or weakened and quickly die. A whitish exudate is occasionally released from the loop. Additional symptoms occur that indicate the development of complications:

• heart function is disrupted;
• arise respiratory diseases;
• the dog urinates frequently; the occurrence of cystitis or pyelonephritis cannot be ruled out;
• the coat becomes dull and disheveled.

Diagnostics

In the acute course of the disease, diagnosis is not difficult. Clinical signs are obvious - if the bitch has recently whelped, then with a high probability the exact cause of the disease is established and treatment is prescribed.

It’s another matter when the clinical symptoms are erased, the female’s reproductive cycle is disrupted, and non-viable offspring are born. In such a situation, the veterinarian takes the following diagnostic actions:

• taking anamnesis;
• inspection;
• additional research.

History taking

The dog trainer should be prepared to provide the veterinarian with the following information:

• date of last heat;
• age of the bitch, number of whelps, their results;
• how did it proceed last pregnancy;
• whether the female experienced imaginary pregnancy.

Inspection

The examination procedure is standard; the veterinarian performs certain diagnostic procedures:

• thermometry;
• examination of the coat and mucous membranes;
• auscultation (listening) of the lungs and heart;
• vaginal clinical examination.

Additional Research

Standard tests include general analysis blood, urine, and ultrasound. At the discretion of the veterinarian, a chest x-ray and an electrocardiogram are taken.

Treatment

Endometritis is treated with medication or surgery.

Drug treatment

The therapeutic strategy is aimed at destroying pathogenic microflora and detoxification. Antibiotic therapy continues for at least a decade, the drug is prescribed veterinarian. Conducted in parallel bacterial analysis vaginal discharge with subtitration for antibiotic sensitivity. If the previous drug turned out to be ineffective, it is replaced.

Depending on the additional symptoms The doctor prescribes detoxification agents, uroseptics, and heart medications. The recovered dog must be bred. If this is not done, there is a high probability of the disease returning.

Surgical treatment

They resort to it when the dog has a serious condition, pyometra or recurrent endometritis has developed. Hormonal surges contribute to the exacerbation of the smoldering process. The operation is performed under systemic anesthesia; the uterus and appendages are removed, as well as the ovaries. This method of treatment not only radically solves the problem of endometritis, but also protects the dog from developing cancer.

Prevention

To prevent endometritis the following actions:

1. Balanced feeding. A half-track delay is a sign that the dog’s diet is insufficient in vitamins, minerals, and essential amino acids. Irresponsible dog handlers use economy class food or feed natural products low nutritional value, as well as questionable freshness - kaltyks, chicken heads, boiled potatoes, grain shit.
2. Regular matings. Hormonal surges that do not lead to conception negatively affect the condition of the reproductive organs.
3. Treatment of imaginary pregnancy. The disease is caused by hormonal fluctuations. It is treatable but prone to relapse. Its complication is chronic endometritis. Females with this pathology are not allowed for breeding, therefore the right decision becomes their sterilization. This means castration of the female with removal of the ovaries, as well as the uterus and appendages.
4. Sterilization. If the owner of a bitch does not plan to get puppies from her, then spaying the dog is a thoughtful solution. The operation eliminates the possibility of inflammation of the endometrium and the formation of cancerous tumors.

Endometritis is a life-threatening disease that is easier to prevent than to treat. An amateur dog handler has a choice - to breed pedigree puppies and risk the health of the pet, or to communicate with an animal that will not get sick until old age.

Endometritis is an inflammation of the inner lining of the uterus. Sometimes the disease is associated with others, such as metritis and pyometra.

The latter is especially dangerous, since with pyometra, pus accumulates in the uterine cavity, which can be fatal. Endometritis can be acute or chronic. In any case, this disease cannot be left to chance. Timely treatment of endometritis will help avoid serious consequences.

Causes of endometritis in dogs

It is generally accepted that only dogs that have given birth are susceptible to endometritis. This is not entirely true. The disease in individuals who have not given birth can be caused by an imbalance of hormones, due to which the uterine mucosa thickens and secretions accumulate inside, which creates a favorable environment for the development of unwanted microflora.

If the infection gets inside, the secretion becomes purulent. Hormonal imbalances can occur in dogs whose estrus cycles have been irregular.

In addition, endometritis can develop during the postpartum period. It is caused by injuries during the birth process: if the puppies are very large or the “caring” owner decides to help the pet without observing obstetric techniques, there is a high probability of ruptures and, as a result, the introduction of pathogenic microflora.

Endometritis is caused by the death of fetuses during pregnancy and their further decomposition - this is a reason to begin immediate treatment.

Symptoms of endometritis

Signs acute form Diseases in a whelping dog may appear 3-5 days after birth. The animal becomes lethargic, refuses food (although it begins to drink heavily), purulent discharge with unpleasant smell. The milk may disappear, or the dog itself may refuse to feed the puppies. In this case, urgent treatment is necessary.

Recognize endometritis in dogs chronic form somewhat more complicated. However, if the dog does not allow males during heat, the puppies are born weak and die with signs of sepsis, and the heats themselves are irregular - it is worth showing the dog to a professional who will prescribe treatment.

How to treat endometritis in dogs

It is very important to start therapy at the first signs of the disease. Otherwise, purulent secretion may enter the blood, which will lead to numerous complications. Conservative treatment Endometritis in dogs involves the use of the drug Argumistin.

It contains silver ions, which successfully fight pathogenic microflora and reduce inflammation. In addition, it contains miramistin. This substance facilitates the dissolution of colloidal silver and the formation of new ions, which makes the treatment even more effective.

The mechanism of action of the antiseptic is absolutely safe for healthy cells and beneficial microflora, since it does not contain antibiotics. Silver particles attack only affected cells, destroying their membranes, and miramistin has an antibacterial effect.

Treatment of endometritis with this drug brings results within 3-5 days. It is administered intrauterinely, 1 time per day, 5-10 ml. This is done using a soft catheter. With the help of Argumistin, therapy is carried out even in pregnant and lactating animals, since the drug is non-toxic and does not harm the offspring.

Endometritis in dogs is inflammation of the endometrium. Distinctive feature This disease (as well as cystic glandular endometrial hyperplasia) is a wide opening of the cervical pharynx with mild main symptoms. In contrast to pyometra (purulent inflammation), when the cervical canal is also open, but such opening occurs much later.

Primary symptoms, causes

Vaginal discharge and colposcopic changes in dogs are most common external symptoms reminiscent of a prolonged estrus. If the corresponding functional disorders prevail, this disease is referred to as the “prolonged estrus” syndrome and appropriate treatment is prescribed. Cystic glandular hyperplasia of the endometrium is expressed in the tuberosity of the uterine walls, and upon palpation there is soreness of the uterine horns and eosinophilia.

The cause of purulent endometritis in dogs lies in an imbalance of hormones, which results in thickening of the uterine mucosa and subsequent accumulation of mucous secretions. When an infection enters the internal cavity of the uterus, the secretion becomes mucopurulent in nature. In cases where the amount of exudate is small, endometritis with slight inflammation is observed.

TO hormonal disorders very often leads to false pregnancy syndrome ( false pregnancy), when after a month and a half after estrus the dog shows clinical signs full pregnancy. False pregnancy can occur even in dogs that have never given birth, and whose estrus usually occurs irregularly.

What should the owner be wary of?

The pet owner should be alerted following symptoms endometritis in dogs: copious, bloody or mucopurulent discharge from the loop. The volume of the abdomen gradually increases, the dog has bad feeling, she is lethargic, passive. The disease is accompanied by severe thirst and lack of appetite, an increase in the amount of urine, and sometimes vomiting.

If even one of these signs is present, the dog must be shown to a doctor. If treatment based on conservative therapy using diuretics does not help, resort to surgical intervention and the uterus and ovaries are removed. Otherwise, after some time the dog will die.

Treatment

It is important to start treating endometritis in dogs as early as possible, since little time passes from the appearance of the first signs of the disease to serious disorders. Purulent discharge, accumulating near the cervix, come out and are also absorbed into the blood. The load on the kidneys increases, gradually they can no longer cope, and chronic renal failure. Due to endometritis, the uterus gradually increases in size, putting pressure on other organs. In addition, there is a danger of uterine rupture with subsequent peritonitis.

Veterinary center "DobroVet"

Endometritis in dogs is inflammation of the inner lining of the uterus. Dangerous disease, which occurs in dogs after childbirth. Although there may be situations when the uterus begins to become inflamed on its own. This is typical for breeds prone to such complications. It is important to notice the symptoms of the disease in time and begin treatment immediately.

Causes of endometritis

Hormonal imbalance causes thickening of the uterine walls and accumulation of mucus. It can be caused by unregulated administration of hormonal medications and poorly performed sterilization. A false pregnancy develops in worst case progressing to endometritis.

Generic problems. For example, unqualified assistance to a woman in labor. Do you doubt that you can properly help your dog give birth? Discuss with your veterinarian in advance the possibility of being present at the birth. Violation hygiene requirements handling tools, dirty hands, and rapid pulling of puppies can cause damage to the mucous membranes of the uterus. During childbirth, the cervix is ​​opened as wide as possible - an ideal passage for pathogens.

The cause is also the afterbirth remaining in the uterus (membranes, parts of the placenta) or the death of the offspring for more early stages pregnancy. The decomposing flesh inside the dog causes rapid proliferation of pathogenic microbes, endometritis turns into purulent (pyometra) at the speed of sound.

A possible reason for the development of endometritis may be too large puppies, distended uterus after childbirth. Compliance with the regime of keeping a dog that has just given birth will allow the organ to quickly return to normal and avoid unpleasant complications.

Infections of the external genitalia can lead to bacteria being ingested. It is necessary to undergo a comprehensive examination in a timely manner veterinary clinic, to cure such diseases in time.

Symptoms of endometritis

The insidiousness of the disease knows no bounds - the first signs of the disease can be diagnosed after a week! The dog suddenly stops eating and constantly wants to drink. The temperature is rising rapidly, the dog is sad.

Fluid then begins to leak from the dog's external genitalia. At first it is bloody, relatively thick, then gradually turns brown and begins to smell unpleasant. The dog leaves wet marks all over the apartment and may often defecate involuntarily. Redness and irritation of the skin are often observed around the anus and vulva.

The chronic course of the disease is manifested by the expiration large quantity disgusting white, green pus. It is quite difficult to determine this type of ailment. However, there are a number of signs that can help.

Warning signs of chronic endometritis

During heat, the dog does not allow the male dog to approach it. The clear cyclical nature of the process is disrupted. After several matings, pregnancy does not occur. After a long labor, puppies are born weakened, non-viable, and quickly die. A pathological autopsy reveals the presence of a poisoned blood supply.

Any of the above signs of endometritis should contact your veterinarian immediately. There are definitely problems with the dog's reproductive system.

Treatment of canine endometritis

Treatment for your dog should begin as soon as possible. The uterus puts pressure on other organs, increases in size, organ rupture is possible - as a result, peritonitis develops. The accumulation of large amounts of mucus directly leads to the formation of pus. The doctor prescribes anti-inflammatory drugs for the dog along with giving the hormone oxytocin. Develops a treatment regimen for endometritis with antibiotics.

Treatment of endometritis in a dog in a veterinary clinic

The antibiotic is selected individually based on the biology of the pathogen. You can't treat your dog at home! Treating with the wrong medications will lead to complications that can actually kill your dog.

Complications of endometritis

The main danger of an untreated illness is pyometra, otherwise purulent endometritis. It develops very quickly, the symptoms of pyometra exponentially increase in strength within just a couple of days. There is only one treatment for this disease – complete removal of the dog’s reproductive organs.

Sepsis (blood poisoning) can begin due to mucus blockage in the cervix. Unable to leak out, the liquid is absorbed into the blood, and a powerful inflammatory process begins. Often there is a refusal to function normally in the kidneys and liver. Treatment may be delayed.

Diseases of the reproductive system in dogs are detected relatively often in veterinary practice. As a rule, these are ordinary and not very dangerous vaginitis, but sometimes bitches with more serious problems turn up at the reception. These include, for example, endometritis in a dog. This pathology is quite difficult and can lead (and often does) either to infertility or cause death. So owners should often pay attention to the condition of their pets, since “harmless” discharge from under the tail may indicate a serious condition of the animal.

First you need to tell us what kind of pathology is called “endometritis”. It's simple. This is a disease accompanied by inflammation of the uterine mucosa. In severe cases of pathology, the inflammatory process can also involve tissues located below the epithelial layer.

Endometritis is possible Classify according to the nature of the exudate released:

• Catarrhal type. IN pure form is relatively rare. With this disease, a thick, mucous, viscous exudate is released from the uterine cavity. As a rule, it is completely transparent, and only sometimes the discharge is somewhat cloudy.
• Purulent endometritis. The most common, common option. As is easy to understand, it is characterized by the release large volumes purulent exudate.
• Necrotic variety. One of the most difficult options. It is characterized by necrotic processes not only in the thickness of the mucous membrane, but also in the underlying tissues.
• Purulent hemorrhagic endometritis. Also a severe variant of the disease. As it develops, pus streaked with bloody inclusions emerges from the animal’s uterine cavity.

According to the type of course, the disease is divided into only two types: endometritis can be acute and chronic. Below we will consider all these varieties in more detail, describing, among other things, its clinical picture.

Clinical picture

Note that the symptoms of endometritis in dogs are in most cases quite standard. A sick dog develops streaks of exudate in the genital area. When drying out, the latter turns into crusts. If an animal has developed necrotic endometritis, it emits an unbearable smell of rot. With purulent inflammation, the pet's genital area is always covered with a greenish-yellow mass.

Despite the abundant discharge from the external genitalia, general state The animal usually remains stable. The exception is advanced cases of purulent endometritis, as well as inflammation, proceeding according to the necrotic type. The latter, by the way, is always accompanied by a sharp deterioration in the animal’s condition. The dog's general body temperature rises, appetite decreases or disappears altogether, and thirst may increase. All this is due to significant intoxication of the body.

If a sufficient amount of exudate accumulates in the uterine cavity, the organ can be easily felt by palpating the abdominal wall. The latter, by the way, swells greatly and sags. In advanced cases, you may think that the dog is pregnant again. With purulent and necrotic endometritis, sepsis is likely to develop. In such cases, the animal’s overall body temperature drops, it becomes lethargic and weak. If you notice these signs in your pet, call your veterinarian immediately, as further delay could cost your dog his life!

And further. Considering that endometritis is almost always accompanied severe intoxication, an excessive burden falls on the animal’s liver and kidneys. If the dog is no longer young and already has problems with these organs (not to mention cases of kidney/liver failure), everything can end very badly.

Symptoms of pyometra

Speaking about the manifestations of endometritis, one cannot fail to mention pyometra, which is often a consequence of this disease. Interestingly, in some cases its first manifestations can be seen during estrus.

The initial symptom of the pathology is a sharp and sudden increase general temperature bodies. However, the appearance of this sign is much more typical on days 20-70 from the end of estrus (Bigliardi and Pamigiani 2004). More than 93% of cases clinical picture pyometra developed at 12 weeks from the end of estrus (Borresen 1979). The pathology develops against the background of glandular hyperplasia and cystic degeneration of the endometrium of the uterus. It is believed that the mentioned proliferative and secretive changes are an effect in response to the action of estrogens and progesterone (hyperestrogenization of the body). In addition, ovarian dysfunction in bitches often contributes to degenerative changes in the uterus, which not only contributes to the development of endometritis and/or pyometra, but also significantly aggravates their course. As for the characteristics of the exudate released from the genital tract of dogs with this pathology... most often it is not there. Only occasionally can a small amount of reddish-gray or brown exudate be seen at the root of the tail of a sick animal, from which a disgusting, putrid odor emanates.

As for the direct “culprits” of endometritis, most often they are gram-negative anaerobic organisms. Symptoms of infection range from obvious and persistent purulent effusion from the uterus to asymptomatic infection. IN severe cases the uterus is swollen with exudate so much that it can be detected by simple palpation of the abdominal cavity.

The presence of purulent effusion in the vagina does not necessarily confirm endometritis: a similar clinical picture is characteristic, as we have already said, of vaginitis, as well as cervicitis (inflammation of the cervix). Diagnosis is especially difficult in small animals, since it is not possible to use a vaginal speculum. Chronic endometritis can be even more difficult to identify, since the animal does not have any clinical manifestations. In such cases, cytology of scrapings of the uterine mucosa is indicated, and ultrasonography or intrauterine biopsy is also necessary.

The danger of all types of endometritis is that they can “mutate” into pyometra. But this disease is much more dangerous and often leads to death.

Physiology and pathophysiology

Modern research has proven that endometritis is a complex pathology, the occurrence and development of which often cannot be explained only by the action of pathogenic microflora that entered the uterus from the outside. This process involves many immunological changes, as well as specific molecular mechanisms responsible for inflammation of the mucous membrane and even the cervix. It is known that the same changes can stimulate the development of pyometra. In addition, a number of foreign researchers insist on the existence of certain genetic mechanisms that also contribute to inflammatory processes in the uterine cavity. But still, all experts agree that endometritis is inextricably (which is not at all surprising) associated with hormonal cycle disorders in animals.

In particular, inflammation of the uterus in more than 70% of cases develops in animals that have a persistent (delayed) corpus luteum in the ovaries. Moreover, it is extremely Negative influence The condition of the uterus is affected by cystic formations in the ovaries. Why does this happen? Everything is quite simple if you know about the basics physiological characteristics canine body. The fact is that hormonal pathologies always have a bad effect on the condition of the mucous membrane of the uterus itself. It degrades, and the natural protection of the organ cavity, which prevents the growth and development of pathogenic microflora, deteriorates. Accordingly, the likelihood of endometritis increases significantly.

The very nature of the uterus plays against the animal. This organ is characterized by the fact that during pregnancy, lymphocytes, protective blood cells, cannot penetrate into its cavity. This “miscalculation” of nature can be explained simply: one cannot allow one’s own the immune system The dogs destroyed the unborn puppies. Of course, endometritis is a disease of animals that have already given birth, but only with hormonal pathologies (especially in the presence of a persistent corpus luteum in the ovary), the body may not “know” that there is actually no pregnancy. So the path to the uterus for lymphocytes is blocked. And one more problem. Hormones released yellow body, greatly reduce the rigidity of the uterine muscles. This leads to subinvolution of the uterus. Simply put, the organ turns into an analogue of an old, flabby sac. Since the uterus cannot contract, practically no exudate leaves its cavity, and all decay products are absorbed into the blood.

Endogenous variant of endometritis

Cystic endometrial hyperplasia-endometritis complex (CEH/P) is one of the most serious and common uterine diseases in bitches. Moreover, scientists came to this conclusion relatively recently (Kida et al. 2006). This pathology is characterized by severe hyperplasia of the walls of the uterus and the penetration of inflammatory factors into all layers of the organ. Interestingly, this phenomenon was first described back in the 80s of the last century. It is believed that this syndrome can occur in dogs in three types, and they are still mistaken for different, unrelated diseases:

• Pyometra.
• Chronic endometritis.
• Cystic glandular endometrial hyperplasia

The exact reasons for this phenomenon have not yet been explained, but it is known that the stimulus for its development is provided by hormonal pathologies and bacterial contamination of the uterus. But the most important role in the development of this type of endometritis, scientists believe, is played by increased production of estrogen. It is caused by ovarian cysts, neoplasia and others negative factors internal environment (Kida et al. 2006). However, the connection between increased levels of sex hormones in the blood and endometritis has been proven relatively long ago (de Bosscher and Ducatelle 2002).

Hormones and endometritis: how are they interconnected?

The problem is aggravated by the fact that estrogens themselves are often prescribed to dogs for certain diseases of the reproductive system. This is due to the fact that they promote the opening of the cervix and increase the rigidity of the muscular lining of the organ. All this promotes the rapid removal of exudate from the organ cavity.

Other hormones are used to stimulate the reproductive cycle and increase the fertility of animals of breeding value. Such drugs are in considerable demand among professional breeders. Unfortunately, progesterones, commonly used for this purpose, can also stimulate the rapid development of endometritis (Nolte et al., 1990). Because of this, veterinary endocrinologists strongly advise against administering hormonal drugs dogs that have not reached at least three years old. The consequences of such rash actions can be extremely serious. The fact is that the effect of progesterone is directly opposite to estrogen: the cervix closes, its rigidity decreases. If there is a pathogenic or conditionally pathogenic microflora in the organ cavity, only favorable environment. Even common E. coli (simple strains), if it entered the uterus before the introduction of hormones, can cause severe necrotizing endometritis (Johnston et al. 1985). In cases where E. coli is represented by more “complex” variants, even strong antibiotics do not always guarantee a cure for the animal.

But the most unpleasant thing is that it is progesterone that enhances the adhesive properties of the uterine membrane, which is why colonies of pathogenic and conditionally pathogenic microorganisms can easily gain a foothold on it. It is assumed that at least 20% of cases of severe endometritis, difficult to treat, have a hormonal etiology. It is also known that this outcome is often caused by unsuccessful intrauterine biopsy, attempts to take scrapings, and... there are many cases where endometritis developed in dogs after caesarean section due to rejection of suture material by the uterine tissue (Noakes et al. 2001).

Thus, today veterinarians are confident in the hormonal origin of most forms of endometritis: bacterial contamination plays only a secondary role in the development of this pathology. As for specific microorganisms, based on a study of surgically removed uteruses, a simple conclusion can be drawn: in approximately 70% of cases, inflammation of the endometrium is caused by the action of pathogenic and conditionally pathogenic forms of Escherichia coli; various shapes streptococci and Pseudomonas aeruginosa. Some authors believe that acute endometritis etiology is more often provoked by the action of hemolytic strains of Escherichia coli (Arora et al. 2006).

Age predisposition

In the relatively distant past, researchers were able to prove that canine endometritis does not have any breed “markers”; all varieties of dogs are equally susceptible to this disease (Niskanen and Trusfield 1998). But the age of animals is a completely different matter. There is a clear correlation here. It is believed that at least 25% of cases of endometritis (that is, a quarter!) of all cases of inflammation of the uterus develop after childbirth in bitches of about ten years of age (Egenvall et al. 2001). Average age animals in which endometritis occurs even more frequently, from six to ten years of age (Niskanen and Trusfield 1998). Experts note that in cases where endometritis has developed in a young dog less than five years old, the disease is more than 70% likely to be of a hormonal nature (which means it needs to be treated with special methods).

But there is another breakdown by age. Blendinger and Bostedt (1991) wrote that only 2% of affected bitches were under two years of age, another 9.3% of dogs were between two and four years of age, 28.5% were animals aged five to seven years, and 42% of affected dogs developed in females at 8-10 years of age. Another 15.5% are pets who fell ill between the ages of 11 and 13 years, and another 2.3% are “veterans” whose age is “off scale” for 13 years.

Therapeutic techniques

Without going into details, there are two types of treatment for endometritis in dogs: medicinal and surgical. The latter is used only in extreme cases when nothing can be done, or endometritis cannot be treated (this often happens when Proteus or Pseudomonas aeruginosa enters the uterine cavity). In addition, about surgery to amputate the uterus for pyometra is a completely “ordinary” measure“, since other treatment methods for this form of endometritis are ineffective, and the pathology itself is extremely dangerous for the health and even the life of the sick animal.

First, I would like to warn dog owners: the use hormone therapy is allowed only in cases where the sick pet is no older than six years old and no younger than three (which we have already indirectly mentioned). At the same time, it is important that there are no significant morphofunctional changes in the uterus itself, since any pathologies during hormonal therapy can lead not only to aggravation of the course of pathological process, but also to the development of neoplasia (that is, cancer). The goal of therapy is to reduce serum progesterone concentrations by administering estrogen.

Please note that this treatment of endometritis in dogs (the drugs used in this case can lead to unpredictable consequences) should only be carried out by a professional veterinarian. Their independent prescription and administration is unacceptable!

Typically, home treatment involves the administration of oxytocin and prostaglandins. Also, Verstegen et al. (2008) proposed transcervical endoscopic probing, which can be used to visually determine the condition of the dog’s uterus. This is very important, since in some cases it is advisable to remove the uterus immediately. Please note that surgical removal organ is strongly recommended in all situations where endometritis is accompanied by ovarian pathologies. Main advantage surgical method– quick leveling of heavy clinical signs such as anorexia, polydipsia, proteinuria and blood poisoning. In milder cases, Amoxicillin is prescribed, and intravenous infusions of anti-toxic compounds (Ringer's solution, 5% glucose) are simultaneously performed. But it is contraindicated for dogs. Better is Ronaxan, a powerful antibiotic from the tetracycline group.

Let us note that today veterinarians do not recommend washing the uterus with antiseptic solutions: it is impossible to completely remove them from the organ cavity, and drug residues only further improve the environment for the development of pathogenic microflora. Much more effective than tablets foaming agents injected directly into the uterus.