Advice for women on how to control the biological clock of skin beauty. When a woman's biological clock is ticking

Delayed pregnancy and a woman's biological clock

This section will be especially useful to those women who, having reached 25-30 summer age, postpone the birth of a child indefinitely, or are simply worried about the condition of their reproductive organs.

If you are planning to delay having a child, you should definitely check your ovarian reserve.

What is a woman’s biological clock or ovarian reserve?

It is known that a girl is born with an already formed number of immature follicles. There are approximately 2,000,000 of them. Before the onset of puberty, despite the fact that there is no ovulation yet, the girl loses 11,000 follicles per month. By the end of puberty and the appearance of regular menstrual cycle about 300,000 - 400,000 follicles remain in the ovaries - this is the original ovarian reserve. From this moment until the onset of age-related menopause (menopause), the ovaries lose 1000 follicles every month. Normally, the ovarian reserve is completely depleted by the age of 45-50 and age-related menopause (menopause) occurs. The body carefully selects eggs for ovulation. Every month, 1000 follicles undergo reverse development (atresia), i.e. about 30 per day. From such huge amount the body selects 1-2 of the highest quality dominant follicles for ovulation and the creation of offspring. Figuratively, the process of atresia of follicles in the ovaries can be called the course woman's biological clock, and on medical language is an age-related depletion of the ovarian reserve.

Without special examination a woman cannot know or feel when her biological clock will stop. This is especially important for those women who decide to postpone having a child at the age of 25-30 for an indefinite period.

It is impossible to stop the biological clock. The phenomenon of age-related decline in ovarian reserve does not depend on the production of any hormones, or on taking birth control pills, or on the number of pregnancies, or on lifestyle or diet.

Infertility and ovarian reserve.

Some girls and women experience premature exhaustion ovarian reserve. Some of them, being able to conceive at 18-25 years old, are no longer capable of this at 35 or even 30 years old, due to a rapid decrease in the number of follicles in the ovaries. By the age of 35, 30% of women from those who were capable of conceiving a child at 18-25 years of age are already infertile.

A sharp decrease in the number of follicles in the ovaries occurs due to various reasons, which are associated with the genetic characteristics of the organism, harmful effects factors environment, various diseases ovarian diseases (eg, polycystic disease), smoking, drinking alcohol, using drugs, exposure to toxic substances and pharmacological drugs (chemotherapy) or radiation (radiation therapy).

It is important to understand that a girl or woman does not and cannot know the initial state of her ovarian reserve. Some women become infertile after 25 years, and some women give birth to healthy offspring even after 40. At the same time, those who lost fertility before the age of 30 do not even know about it at first. This does not manifest itself in any way and becomes clear only after the woman has decided to give birth to a child, but for a long time desired pregnancy doesn't come.

Most important issue for a woman is “When will she become infertile?” And help in answering this question can determine the number of follicles in the ovaries capable of ovulation and the rate at which their number decreases over time.

How to determine ovarian reserve?

Counting the number of antral follicles in the ovaries and determining the level of anti-Mülerian hormone and estrogen can help in this matter.

The number of follicles is counted using ultrasound high resolution. The level of anti-Mullerian hormone and estrogen is determined in the blood serum.

Based on the data obtained, you can judge the condition of the ovaries, how depleted their ovarian reserve is in relation to your age, and what are your chances and prospects of becoming pregnant in the coming years.

What to do if the ovarian reserve is reduced or progressively reduced?

If your ovarian reserve is reduced and you are not planning to have a child in the near future, you can effectively preserve your ability to bear a child.

1. Store ovarian tissue with a not yet exhausted supply of follicles in the Cryobank. When you decide to give birth to a child, your ovarian tissue is removed from the Cryobank, thawed and implanted into your body on the ovary (the function of which may have already faded by this time). Once she implants and begins to ovulate, you can get pregnant. Your natural hormonal background, the onset of menopause (menopause) will be delayed.

2. Save the egg or embryo. Subsequently, when you decide to become pregnant, the stored egg, after thawing, is fertilized and implanted in your uterus to initiate pregnancy. The thawed and viable embryo is implanted into the prepared uterus immediately.

If necessary, you can use your eggs or embryos stored in the Cryobank to give birth to a child by a surrogate mother.

The ovarian tissue stored in the Cryobank can be replanted only for you and no one else, unless you have an identical twin sister.

How to use fertility preservation methods?

You can check your ovarian reserve and have ovarian tissue collected at one of our partner clinics, whose specialists have extensive experience in restoring reproductive health.

You can also use the services of any other reproductive health clinic to assess the ovarian reserve and carry out the procedure for collecting ovarian tissue. Our Cryobank specialists will arrive there with a special shipping container to deliver the resulting ovarian tissue to the Cryobank laboratory, where the cryopreservation procedure will be carried out. After which the material is placed in liquid nitrogen and stored in cryogenic storage at a temperature of -196 degrees Celsius.

Ovarian tissue collection is performed laparoscopically. This method today has the least number of contraindications and complications.

Cryopreservation of part of an ovary will not reduce your ability to conceive a child naturally, but will be a reliable “biological insurance” policy in the event that your ovaries stop ovulating normally over time.
In the future, if you are unable to conceive a child naturally due to a sharp decrease or absence of normal ovarian function, your own cryopreserved, still healthy ovarian tissue can help you.

Ovarian tissue is removed from the cryobank, thawed and replanted back into the body in its natural location (on the ovary or at its anatomical location). Once the tissue has implanted and begins to ovulate, you can plan to conceive a child. Conception can occur naturally or with the help of assisted reproductive technologies.

The procedure for reverse transplantation of cryopreserved ovarian tissue should be performed by highly qualified doctors dealing with the problems of restoring reproductive function. Such specialists work in partner clinics. You can also contact any other clinic that has experience in autotransplantation of ovarian tissue both in Ukraine and abroad. The Cryobank of Human Reproductive Cells and Tissues of the Institute of Cell Therapy can provide you with cryopreserved ovarian tissue in a special transport Dewar vessel with liquid nitrogen, in which you can deliver it to any clinic in Europe, Israel or the USA, where it has been used for a long time and has been successfully used this method. The Institute of Cell Therapy will undertake the preparation of all necessary documents.

Job internal organs person by the hour

Our ancestors knew that all people, animals and plants have the ability to sense time, or, as they say now, they felt their biological clock and lived in accordance with their biological rhythm. Change of seasons of the year, lunar cycles, day and night are directly related to this clock.
IN daytime Metabolic processes aimed at extracting energy from accumulated nutrients predominate in our body. At night, the energy supply spent during the day is replenished, regeneration processes are activated, tissue restoration occurs and internal organs are “repaired.”

WHY IS IT BETTER TO START YOUR DAY AT 6 AM?

or How to restore the biological clock of the DAY?

Heart, liver, lungs, kidneys - all organs live and work according to the clock, each has its own peak of activity and period of recuperation. And if, for example, you force the stomach to work at 21:00, when the “day regimen” provides for rest, the acidity of gastric juice increases by a third above normal, which leads to the development of gastrointestinal pathologies and exacerbation of peptic ulcers. Night exercise is also contraindicated for the heart: a failure in the daily activity of heart muscle cells is fraught with hypertrophy with the subsequent development of heart failure.

Body schedule hourly from 4:00 to 22:00

04:00 — The adrenal cortex is the first to “wake up”: from 4 in the morning it begins to produce hormones that excite the nervous system. The most active, cortisol, increases blood glucose levels and also blood pressure, which tones the blood vessels, increases the rhythm of the heartbeat - this is how the body prepares for the upcoming daily stress. There is a sharpening of hearing: the slightest noise - and we wake up. At this hour, peptic ulcer disease often reminds itself, and attacks occur in patients with asthma. Blood pressure during this period is low, the brain is poorly supplied with blood - this hour is also called the fatal hour, from 4 to 5 am sick people often die.
Division occurs and the most active renewal occurs the largest number cells. Cell growth hormones are actively produced. The skin is actively renewed.

In terms of energy: from 3 to 5 o'clock
The lung meridian begins to work actively. During the hours of his activity, energy and blood move from a state of calm to movement and begin to spread throughout the body. At this time, all organs of the human body should rest. Only in this way can the lungs rationally distribute energy and blood.

05:00 — We have already changed several phases of sleep: the phase of light sleep, dreaming and the phase deep sleep dreamless. Anyone who gets up at this time quickly comes to a cheerful state. The large intestine begins to work - the time comes to release toxins and waste. The body begins to become more active, blood pressure and hormone levels increase, and defenses are activated.
06:00 — Blood pressure and temperature begin to rise, and the pulse quickens. We are waking up. Promotion blood pressure(by 20-30 points), the risk of hypertensive crises, strokes, heart attacks. The level of adrenaline in the blood increases. This is the best time to take a shower.

In terms of energy: from 5 to 7 am
the work of the colon meridian is activated, which is responsible for the final elimination from the body feces with toxins and waste.
When you wake up, it is advisable to immediately drink a glass of warm water on an empty stomach; it helps to moisturize the intestinal tract, stimulate bowel movements and eliminate toxins. This is especially true for those who suffer from frequent constipation.

07:00 — The stomach is activated: the body requires replenishment of nutrients in order to extract energy from them. Carbohydrates that enter the body are actively decomposed; during this period no active body fat. The body's immune defense increases. The chance of infection through contact with viruses is minimal. Blood viscosity is increased, the level of adrenaline in the blood is increased. For heart patients and hypertensive patients this is the most dangerous time days. Physical activity is not recommended. The body's sensitivity to aspirin increases and antihistamines: taken at this time, they remain in the blood longer and act more effectively.
08:00 “The liver has completely freed our body of toxic substances. You should not drink alcohol at this hour - the liver will experience increased stress. Activated sexual activity. A person experiences sexual arousal.
09:00 — Mental activity increases, sensitivity to pain decreases. The heart works more energetically. It is not recommended to spend this time sports training. The level of cortisol in the blood is very high.

Seasonal rhythms of human organs

In terms of energy:from 7 to 9 am
The stomach meridian is active. This time is considered ideal for breakfast; the work of the spleen and stomach is activated, making food digested very easily. And if you don’t have breakfast at this time, then during the hours of greatest activity of the stomach meridian, an empty stomach will have “nothing to do.” With the greatest activity of the stomach meridian, the level of acids in the gastric juice increases, and excess acid harms the stomach and threatens the occurrence of stomach diseases and violation acid-base balance in organism.

10:00 — Our activity is increasing. We are in in better shape. This enthusiasm will continue until lunch. Don’t waste your ability to work, because later it won’t appear in this form.
11:00 — The heart continues to work rhythmically in harmony with mental activity. A person does not give in to fatigue. Active growth of nails and hair occurs. Increased sensitivity to allergens.

In terms of energy: from 9 to 11 o'clock
The spleen meridian is active. The spleen is involved in digestion, assimilates and distributes nutrients and fluids extracted from food throughout the body.
The brain is active. Therefore, these hours are called the “golden period”, i.e. as efficient as possible in terms of work and study. Don't forget to have breakfast. After breakfast, the spleen absorbs food coming from the stomach, and the muscles, having received nutrients, become more active. A person has a desire to activate his muscles. When the energy of the muscles and muscles is spent, the work of the spleen is even more activated, and therefore it turns out that this organ is “busy” all the time, loaded with work.

12:00 — The first decline in activity is coming. Physical and mental performance. You feel tired and need rest. During these hours, the liver “rests” and some glycogen enters the blood.
13:00 — The energy is decreasing. Reactions slow down. The liver is resting. A slight feeling of fatigue appears, you need to rest. If you have lunch at this time, the food will be absorbed faster.

In terms of energy: from 11 to 13 pm
The heart meridian is active. During these hours, energy reaches its peak, which can lead to an excess of heart “fire.” The easiest way to eliminate this excessive “fire” is to take a short lunch break. This will help replenish your energy and increase your productivity in the afternoon. Eating lunch helps prevent heart disease.

14:00 - Fatigue goes away. Things are getting better. Efficiency increases.
15:00 — The senses become more acute, especially the sense of smell and taste. We are getting back to work. This is a time of partial or complete immunity of the body to medications. The organs of the body become very sensitive. Appetite increases.

In terms of energy: from 13 to 15 hours
meridian is active small intestine. Nutrients enter the small intestine, where they are processed and broken down, and then transported to various organs of the human body through the blood and lymphatic capillaries. It is recommended to drink more water to thin the blood and protect the blood vessels.
Weakened small intestinal function not only causes low energy and blood levels, but also reduces waste elimination.

16:00 - Blood sugar levels rise. Doctors call this condition afternoon diabetes. However, such a deviation from the norm does not indicate a disease. Second surge in activity. The blood is again enriched with oxygen, the work of the heart and lungs is activated. Favorable time For physical activity and exercises.
17:00 — High performance is maintained. Class time for fresh air. The body's performance and endurance approximately doubles. Activation occurs endocrine system, especially the pancreas. At this time, you can take more food. Due to active digestion and complete breakdown of foods, fat will not be deposited.

In terms of energy: from 15 to 17 hours
During these hours the bladder meridian is active, and bladder is the main channel for removing waste and toxins. This is why you need to drink more water during this time. At this time, a person is full of strength and energy. Metabolism in the body reaches its peak, the brain received the necessary portion of nutrients after lunch. Therefore, this time is called the second “golden period” for work and study. Reaches a peak - metabolism.

18:00 — People's sensitivity to pain decreases. The desire to move more increases. Mental alertness gradually decreases.
19:00 - Blood pressure increases. Mental stability is zero. We are nervous, ready to quarrel over trifles. Cerebral blood flow decreases and headaches begin.

In terms of energy: from 17 to 19 hours
At this time, the kidney meridian is active. This is the peak period for removing waste and toxins from the body, so you should increase the amount of drinking to speed up the appearance of urine and stimulate the elimination of unnecessary and harmful substances. At the same time, the kidneys begin to preserve the most valuable substances. If you make a habit of drinking a glass of water during these hours, you will improve your kidney health.

20:00 — Our weight by this hour reaches highest values. Reactions to external stimuli are clear and fast.
21:00 - Activity nervous system normalizes. Psychological condition stabilizes, memory becomes sharper. This period is especially good for those who need to memorize a large number of information, such as texts or foreign words.

In terms of energy: from 19 to 21 hours
are considered the third “golden period” for work and study. At this time, when the pericardial meridian is active, the entire body is calm. After light dinner you can go for a walk. Before 21:00 it is useful to drink a glass of water or weak tea. At this time, the pericardial meridian should be massaged. Massage of the pericardial meridian helps to strengthen the function of the heart, as a result of which the activity of all internal organs improves and the circulation of energy and blood is activated.
The pericardial meridian is one of the 12 main active channels. He passes through inside hands You can, for example, while sitting in front of the TV, knead from the armpit down left hand right hand– along the pericardial meridian, and then do the same with the right hand. You need to massage each hand for 10 minutes.

WHY DOES OUR BODY NEED REST AT NIGHT?

or How to restore the biological sleep clock?

How to restore your biological sleep clock

Nature has determined that we spend thirty percent of our lives sleeping: the body needs rest and regeneration. But we often save on sleep, paying for it with psycho-emotional disorders, endocrine disruptions, gastrointestinal and heart diseases, and sometimes oncology. And if innocent insomnia has come to your attention, this is not only the consequences of a disruption in clock rhythms, but also a reason to think about the REASONS for a whole list of pathologies that inevitably lead us to illness and old age.

At night, the pineal gland (the pineal gland in the sulcus of the midbrain) produces melatonin - the peak of activity occurs at approximately 2 a.m., and by 9 a.m. its content in the blood drops to its minimum values. It is produced by the pineal gland only at night because the active enzymes involved in its production are suppressed by DAYlight. Thanks to melatonin, there is a comfortable decrease in temperature and blood pressure, they slow down their activity and physiological processes. At night, only the liver actively works - it cleanses the blood of pathogenic flora of waste and toxins. Another one is starting to work actively important hormone– somatotropin (growth hormone) that stimulates cell reproduction, regeneration, rejuvenation and anabolic processes (the release of substances beneficial to the body from food). Failure to adhere to a sleep schedule leads not only to insomnia, oncology and diabetes mellitus, and also early aging body...

Body schedule from 22:00 to 4:00

22:00 - Body temperature decreases. The number of leukocytes - white blood cells - increases. In the body of those who go to bed at this time, melatonin, the hormone of youth, is produced with redoubled force.
23:00 — If we sleep, the cells restore their functions. Blood pressure decreases, pulse becomes slower. Metabolism slows down. At this time the body is most prone to developing inflammatory processes, colds, infections. Eating late is very harmful.

In terms of energy: from 21 to 23 hours
At this time, people complete their daily activities and prepare for bed. Therefore, during these hours you need to calm down and ensure yourself good vacation. If you violate this natural law, you can harm your health.
If a person sleeps poorly or insufficiently, he begins to feel unwell, he is overcome by lethargy and apathy.
To have quality sleep, you need to fall asleep before 11:00 pm.

24:00 - This last hour days. If we went to bed at 10 pm, then it’s time for dreams. Our body, our brain sums up the past day, leaving what is useful and rejecting everything unnecessary.
01:00 – We have been sleeping for about three hours, having gone through all phases of sleep. At one o'clock in the morning the light phase of sleep begins, we can wake up. At this time we are especially sensitive to pain.

In terms of energy: from 23 to 1 o'clock
The gallbladder meridian is active. At this time, yin energy gradually dissipates and fades away, but yang energy is born - the most powerful productive life force. If we follow the regime and go to bed before 23:00, then yang energy quickly arises and rises, which benefits our entire body. If it is later, then the “yang” energy begins to be wasted. But it is precisely this that is the basis of life.

02:00 – Most of our organs operate in an economical mode. Only the liver works. It intensively processes the substances we need. And above all, those that remove all poisons from the body. The body undergoes a kind of “big wash.”
03:00 - The body is resting. Deep sleep. The muscles are completely relaxed. Pulse and breathing rates decrease, brain wave activity decreases, heart rate slows, body temperature and blood pressure drop. At three o'clock in the morning, energy consumption in the body is replenished.

In energy In other words: from 1 to 3 o'clock
At this time, the liver meridian is activated. The removal of toxins and waste occurs, as well as the regulation and renewal of blood. The best way to strengthen the liver - good quality sleep. The deeper it is, the better the blood circulates and the more active the liver cleansing occurs.

Try to follow a daily routine: eat at the same time, wake up at 6:00, go to bed no later than 22:00 and then you will remain young, healthy and full of energy for a long time! By the way, this is exactly what our ancestors did: they rose at dawn and went to bed at nightfall - probably not only because of the lack of electricity.

We wish you health and prosperity!

We all constantly hear about the mythical “biological clock” that is constantly ticking until a woman has a child. Along with the biological ones, career hours, travel hours, and any other dreams that get in the way of marriage, children, and responsibility also work.

More and more more women prefer to ignore their biological clock. On average, a woman has a child for the first time five years later than in the seventies of the last century. What happens if you wait? Let's look at this issue in detail.

Wasting time

First of all, you need to figure out what a biological clock actually is. It is a widely held belief that women only have certain time to start a family. In fact, this is a rather stereotypical idea, far from the truth. Women and men have several different biological clocks. These clocks are collections of certain molecules in cells throughout the body. They create the circadian rhythm, which determines when we eat, sleep, and do everything else.

The main clock is located in the brain, it determines all processes - sleep, digestion, the menstrual cycle. This clock does not speed up unless a person disrupts its timing. poor nutrition, overwork or decreased physical activity. One way or another, the concept that states that for a woman to become pregnant only short term, determined by these hours, is completely incorrect - the situation is much more complex and multifaceted.

Complete fiction

The idea that there is a biological clock that determines the ability to conceive first appeared in newspapers in 1978 - it was new concept to intimidate young women seeking active career growth.

You've probably heard the phrase "woman's biological clock," but what does that really mean and at what age should you start worrying about it? A man will produce sperm almost the same throughout his life, but for women everything is different...

• You are born with a lifetime supply of eggs.
• No new eggs are produced during life.

Woman's biological clock

Let's start by looking at biology. You are born with a lifetime supply of eggs, and no more are produced. Moreover, greatest number A woman's egg count is observed while she is still in the womb: a 20-week female fetus has about seven million eggs. By the time you're born, this number drops to about two million, and by the time you reach puberty and start your period (periods), you'll have about 300,000 to 500,000 eggs left.

However, you should not worry about your egg supply constantly decreasing, as this is a natural and continuous process that is completely independent of birth control pills, pregnancy, food additives and even on health status or lifestyle.

Your fertility is greatest between the ages of 20 and 30, and fertility declines from about age 35 until menopause. After menopause, it is impossible to get pregnant naturally.

During most menstrual cycles, one of your eggs matures and is released from the ovary in preparation for fertilization (ovulation occurs). However, the decline in the number of eggs (also called the "ovarian reserve") occurs more quickly, and from the time you start menstruating, approximately 1,000 eggs are destined to die each month. Over the course of your life, your ovaries will release about 500 mature eggs. Once your supply of eggs is depleted, your ovaries will stop producing estrogen and you will go through menopause. For most women this happens around age 50: average age in developed countries - 51.4 years. From this point on, you will no longer be able to get pregnant naturally.

I heard that there is a test that can measure the number of eggs I have left. I read that for this you need to undergo blood tests for anti-Mullerian hormone and FSH. What does this mean?

Professor Michael Thomas

For women over 35 who are trying to get pregnant, there are a number of tests that can be done to predict her ovarian reserve (how many eggs she has left). Blood tests include an anti-Mullerian hormone (AMH) test, which can be done at any time during your menstrual cycle, even if you are taking birth control pills. Anti-Mullerian hormone is produced by cells in the ovarian follicles and allows for early stages determine the remaining ovarian reserve. The interpretation of the results of this test may vary between doctors.
In addition, on the third day of the menstrual cycle (two days after the start of menstruation), you can take a blood test for follicle-stimulating hormone (FSH) and estradiol. These two tests can detect a decrease in ovarian function at the beginning of the menstrual cycle, when the dominant follicle is preparing for ovulation. Another test to determine low ovarian reserve is the “antral follicle count.” During this test, a transvaginal ultrasound is performed to determine the number of follicles that are ready to ovulate on the third day of the cycle. More detailed information information about ovarian reserve testing can be found on the website

The body of men, women and each person individually is very individual, and there are different biologicalwatch when the body is especially active or requires rest. Knowing the secret of her own biological clock and using it wisely, a woman can prolong her youth, become beautiful and attractive, improve her well-being, restore her health and even achieve success in life!

Meal hours:

1. Breakfast the best way absorbed by the body in morning time from 8 to 9 o'clock. At this time, the body has a better metabolism and works great digestive system. Closer to 11:00 in the afternoon, you can take a break for a light snack.

2. One o'clock in the afternoon is the best time for a lunch meal; after lunch, the body is at its best. a short time goes into a state of sleep, so you shouldn’t be too busy with work at this hour.

3. The most the right time for dinner - 17:00, but if you can’t eat at this time, you can still have dinner before 20:00 in the evening. After eight, eating is not recommended, since from this hour the body begins to require rest.

Activity time:

1. Best time according to biological clock For physical exercise and morning jogging - 7:30 am, at this time the body begins to wake up at an accelerated speed.

2. For owls and larks, peak activity occurs at 10:00 am. From now until noon brain activity activates all its capabilities, and these watches are best suited for intellectual work and solving complex problems.

A new boost of energy comes to the body at 17:00 in the evening. From now on, you can devote a whole hour to active physical activities in the fresh air.

Rest, sleep

After waking up, the next sleep break is best taken after the lunch meal - somewhere from 13:00 to 14:30. According to scientists, the daily half-hour nap literally prolongs life. Next hours until 20:00 you need to spend it very actively, and from eight again allow the body to relax, for example, with a pleasant massage. Best time for sleep (as they say The biological clock body) - eleven o'clock at night, heartbeat by this time it slows down, the body requires deep rest in the form of sleep.

Beauty watch

Women need to remember three main points:

1. Woman's face It looks worst during the day: from 13:00 to 14:00. It is at this hour that wrinkles on the face become most noticeable, the skin becomes tired. appearance and needs rest.

2. From 15:00 to 18:00 is the most useless time for cosmetic procedures. At this time, the skin completely loses its sensitivity, so all kinds of masks, spas and peeling procedures will not give any result.

3. For a woman Special attention should be given to the skin from 18:00 to 23:00. All care procedures and It is better to cleanse at this time, the skin intensively absorbs oxygen and blood circulation is activated.

Love time

As a result of long-term research by German scientists, it was proven that The biological clock The activity of the genital organs of men and women is practically not the same. For women, this time comes after 22:00 in the evening - female libido increases and the “attachment” hormone prolactin begins to be released. The only hour of contact between male and female activity is approximately 16:00 in the evening, but at this time on weekdays people are usually busy with household chores, although on weekends it is worth trying to give in to biorhythms.

It's just general description human biological clock. First of all, you should always listen to your own body learn to pay proper attention natural desire sleeping, eating or resting.